ABSTRACT
Background: The present study was carried out to investigate the possible protective effects of royal jelly [RJ] on oxymetholone [OXM]-induced oxidative liver injuries in mice
Methods: In total, 32 adult male NMRI mice were divided into four groups of eight mice each. Mice in groups 1 and 2 were orally administered 5 mg/kg/day OXM for 30 days. At the same time, mice in group 3 received RJ at a dose of 100 mg/kg/day. Saline control and RJ control groups were also included in this study
Results: Administration of 5 mg/kg OXM resulted in a significant decrease in total antioxidant capacity and catalase activity, as well as a significant increase in malondialdehyde [P<0.05]. In addition, OXM-administrated mice showed a slight increase in liver enzymes, including alanine amino transferase, aspartate amino transferase, and alkaline phosphatase. Although OXM caused histopathological changes in the liver, RJ could significantly improve all of the above-mentioned parameters at a dose of 100 mg/kg
Conclusion: The results of the present study indicated that RJ has a partially protective effect on OXM-induced liver toxicity in mice
ABSTRACT
Objective: This study aimed to investigate the effects of royal jelly [RJ] on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone [OXM]
Materials and Methods: In this exprimental study, 32 male and 96 female adult Naval Medical Research Institute [NMRI] mice [7-9 weeks of age] with a ratio of 1:3 for fertilization purposes were randomly divided into 4 groups as follows: i. Control group [n=8] receiving 0.1 ml/mice saline daily by gavage for 30 day, ii. RJ group [n=8] treated with RJ at a dose of 100 mg/kg daily by gavage for 30 days, iii. OXM group [n=8] receiving OXM at the dose of 5 mg/kg daily by gavage for 30 days and iv. RJ+OXM group [n=8] receiving RJ at the dose of 100 mg/kg daily by gavage concomitant with 100 mg/kg OXM administration for 30 days
Results: Analysis revealed a significant reduction in catalase, total antioxidant, as well as embryo development in OXM group [P<0.05]. However, RJ group showed a salient recovery in the all of the above mentioned parameters and embryo toxicity
Conclusion: The results of this study indicated a partially protective effect of RJ against OXM-induced embryo toxicity